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Science 11 April 1980:
Vol. 208. no. 4440, pp. 200 - 202
DOI: 10.1126/science.7361118
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Articles

Science, Vol 208, Issue 4440, 200-202
Copyright © 1980 by American Association for the Advancement of Science

articles

Faster cholinergic REM sleep induction in euthymic patients with primary affective illness

N Sitaram, JI Nurnberger Jr, ES Gershon, and JC Gillin

Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)