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Science 11 April 1980:
Vol. 208. no. 4440, pp. 198 - 200
DOI: 10.1126/science.7361117
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Articles

Science, Vol 208, Issue 4440, 198-200
Copyright © 1980 by American Association for the Advancement of Science

articles

Magnesium deficiency produces spasms of coronary arteries: relationship to etiology of sudden death ischemic heart disease

PD Turlapaty and BM Altura

Isolated coronary arteries from dogs were incubated in Krebs-Ringer bicarbonate isolation and exposed to normal, high, and low concentrations of magnesium in the medium. Sudden withdrawal of magnesium from the medium increased whereas high concentrations of magnesium decreased the basal tension of the arteries. The absence of magnesium in the medium significantly potentiated the contractile responses of both small and large coronary arteries to norepinephrine, acetylcholine, serotonin, angiotensin, and potassium. These data support the hypothesis that magnesium deficiency, associated with sudden death ischemic heart disease, produces coronary arterial spasm.


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