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Science 11 April 1980:
Vol. 208. no. 4440, pp. 185 - 188
DOI: 10.1126/science.7361114
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Articles

Science, Vol 208, Issue 4440, 185-188
Copyright © 1980 by American Association for the Advancement of Science

articles

A nonadrenergic vagal inhibitory pathway to feline airways

L Diamond and M O'Donnell

In cats anesthetized with chloralose-pentobarbital and artificially ventilated, electrical stimulation of the caudal end of the cut cervical vagus nerve has a biphasic effect on the bronchoconstriction induced by an intravenous infusion of serotonin. The response consists of a brief augmentation of bronchoconstriction followed by relatively prolonged bronchodilation. After muscarinic receptor blockade with atropine, vagal stimulation causes only bronchodilation. Vagally mediated bronchodilation is not affected by beta adrenergic blockade with propranolol, alpha adrenergic blockade with phenoxybenzamine, or adrenergic neuronal blockade with guanethidine, but is abolished by autonomic ganglionic blockade with hexamethonium. These findings support the conclusion that a nonadrenergic inhibitory nervous system is present in the pulmonary airways of the cat and that the system is supplied by preganglionic fibers in the cervical vagus nerves.


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