Science 11 April 1980: Vol. 208. no. 4440, pp. 177 - 179 DOI: 10.1126/science.6987736

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Articles

Single-cell response to stiffness exhibits muscle-like behavior.

D. Mitrossilis, J. Fouchard, A. Guiroy, N. Desprat, N. Rodriguez, B. Fabry, and A. Asnacios (2009)
PNAS 106, 18243-18248
 |  Abstract »  |  Full Text »  |  PDF »

Mechanotransduction - a field pulling together?.

C. S. Chen (2008)
J. Cell Sci. 121, 3285-3292
 |  Abstract »  |  Full Text »  |  PDF »

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.

H. Hirata, H. Tatsumi, and M. Sokabe (2008)
J. Cell Sci. 121, 2795-2804
 |  Abstract »  |  Full Text »  |  PDF »

Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network.

P. Skoglund, A. Rolo, X. Chen, B. M. Gumbiner, and R. Keller (2008)
Development 135, 2435-2444
 |  Abstract »  |  Full Text »  |  PDF »

Measurement Techniques for Cellular Biomechanics In Vitro.

K. A. Addae-Mensah and J. P. Wikswo (2008)
Experimental Biology and Medicine 233, 792-809
 |  Abstract »  |  Full Text »  |  PDF »

Actin stress fibres.

S. Pellegrin and H. Mellor (2007)
J. Cell Sci. 120, 3491-3499
 |  Abstract »  |  Full Text »  |  PDF »

Finite deformation mechanics in buckled thin films on compliant supports.

H. Jiang, D.-Y. Khang, J. Song, Y. Sun, Y. Huang, and J. A. Rogers (2007)
PNAS 104, 15607-15612
 |  Abstract »  |  Full Text »  |  PDF »

Pericyte Rho GTPase Mediates Both Pericyte Contractile Phenotype and Capillary Endothelial Growth State.

M. E. Kutcher, A. Y. Kolyada, H. K. Surks, and I. M. Herman (2007)
Am. J. Pathol. 171, 693-701
 |  Abstract »  |  Full Text »  |  PDF »

SINGULAR BEHAVIOUR IN A GENERALIZED BOUNDARY EIGENVALUE PROBLEM FOR ANNULAR PLATES IN TENSION.

C. D. Coman and A. P. Bassom (2007)
Q J Mechanics Appl Math
 |  Abstract »  |  Full Text »  |  PDF »

Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement.

M. L. Lombardi, D. A. Knecht, M. Dembo, and J. Lee (2007)
J. Cell Sci. 120, 1624-1634
 |  Abstract »  |  Full Text »  |  PDF »

Contractility as a Prerequisite for TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts.

T. Meyer-ter-Vehn, S. Sieprath, B. Katzenberger, S. Gebhardt, F. Grehn, and G. Schlunck (2006)
Invest. Ophthalmol. Vis. Sci. 47, 4895-4904
 |  Abstract »  |  Full Text »  |  PDF »

Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells.

P. Sancho-Bru, R. Bataller, J. Colmenero, X. Gasull, M. Moreno, V. Arroyo, D. A. Brenner, and P. Gines (2006)
Am J Physiol Gastrointest Liver Physiol 291, G877-G884
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of elongation in embryogenesis.

R. Keller (2006)
Development 133, 2291-2302
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Cells Feel and Respond to the Stiffness of Their Substrate.

D. E. Discher, P. Janmey, and Y.-l. Wang (2005)
Science 310, 1139-1143
 |  Abstract »  |  Full Text »  |  PDF »

Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of {alpha}-SMA and NF-{kappa}B.

S. Baouz, J. Giron-Michel, B. Azzarone, M. Giuliani, F. Cagnoni, S. Olsson, R. Testi, G. Gabbiani, and G. W. Canonica (2005)
Int. Immunol. 17, 1473-1481
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular matrix (ECM) microstructural composition regulates local cell-ECM biomechanics and fundamental fibroblast behavior: a multidimensional perspective.

A. M. Pizzo, K. Kokini, L. C. Vaughn, B. Z. Waisner, and S. L. Voytik-Harbin (2005)
J Appl Physiol 98, 1909-1921
 |  Abstract »  |  Full Text »  |  PDF »

FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness.

H. J. Kong, T. R. Polte, E. Alsberg, and D. J. Mooney (2005)
PNAS 102, 4300-4305
 |  Abstract »  |  Full Text »  |  PDF »

Force mapping in epithelial cell migration.

O. du Roure, A. Saez, A. Buguin, R. H. Austin, P. Chavrier, P. Silberzan, and B. Ladoux (2005)
PNAS 102, 2390-2395
 |  Abstract »  |  Full Text »  |  PDF »

Slipping or Gripping? Fluorescent Speckle Microscopy in Fish Keratocytes Reveals Two Different Mechanisms for Generating a Retrograde Flow of Actin.

C. Jurado, J. R. Haserick, and J. Lee (2005)
Mol. Biol. Cell 16, 507-518
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic changes in keratocyte speed and traction stress arise from Ca2+-dependent regulation of cell adhesiveness.

A. D. Doyle and J. Lee (2005)
J. Cell Sci. 118, 369-379
 |  Abstract »  |  Full Text »  |  PDF »

Adhesion-contractile balance in myocyte differentiation.

M. A. Griffin, S. Sen, H. L. Sweeney, and D. E. Discher (2004)
J. Cell Sci. 117, 5855-5863
 |  Abstract »  |  Full Text »  |  PDF »

Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments.

A. J. Engler, M. A. Griffin, S. Sen, C. G. Bonnemann, H. L. Sweeney, and D. E. Discher (2004)
J. Cell Biol. 166, 877-887
 |  Abstract »  |  Full Text »  |  PDF »

Integrins in Mechanotransduction.

A. Katsumi, A. W. Orr, E. Tzima, and M. A. Schwartz (2004)
J. Biol. Chem. 279, 12001-12004
 |  Abstract »  |  Full Text »  |  PDF »

Engineering biological structures of prescribed shape using self-assembling multicellular systems.

K. Jakab, A. Neagu, V. Mironov, R. R. Markwald, and G. Forgacs (2004)
PNAS 101, 2864-2869
 |  Abstract »  |  Full Text »  |  PDF »

Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion.

D. Lehnert, B. Wehrle-Haller, C. David, U. Weiland, C. Ballestrem, B. A. Imhof, and M. Bastmeyer (2004)
J. Cell Sci. 117, 41-52
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Corneal Fibroblast Contractility within Fibrillar Collagen Matrices.

M. Vishwanath, L. Ma, C. A. Otey, J. V. Jester, and W. M. Petroll (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4724-4735
 |  Abstract »  |  Full Text »  |  PDF »

Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface.

O. D. Gil, T. Sakurai, A. E. Bradley, M. Y. Fink, M. R. Cassella, J. A. Kuo, and D. P. Felsenfeld (2003)
J. Cell Biol. 162, 719-730
 |  Abstract »  |  Full Text »  |  PDF »

Cell organization in soft media due to active mechanosensing.

I. B. Bischofs and U. S. Schwarz (2003)
PNAS 100, 9274-9279
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction.

N. V. Bogatcheva, A. D. Verin, P. Wang, A. A. Birukova, K. G. Birukov, T. Mirzopoyazova, D. M. Adyshev, E. T. Chiang, M. T. Crow, and J. G. N. Garcia (2003)
Am J Physiol Lung Cell Mol Physiol 285, L415-L426
 |  Abstract »  |  Full Text »  |  PDF »

Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts.

W. M. Petroll, L. Ma, and J. V. Jester (2003)
J. Cell Sci. 116, 1481-1491
 |  Abstract »  |  Full Text »  |  PDF »

Tensegrity I. Cell structure and hierarchical systems biology.

D. E. Ingber (2003)
J. Cell Sci. 116, 1157-1173
 |  Abstract »  |  Full Text »  |  PDF »

Contraction of Cultured Human Uterine Smooth Muscle Cells after Stimulation with Endothelin-1.

E. Dallot, M. Pouchelet, N. Gouhier, D. Cabrol, F. Ferre, and M. Breuiller-Fouche (2003)
Biol Reprod 68, 937-942
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Cells lying on a bed of microneedles: An approach to isolate mechanical force.

J. L. Tan, J. Tien, D. M. Pirone, D. S. Gray, K. Bhadriraju, and C. S. Chen (2003)
PNAS 100, 1484-1489
 |  Abstract »  |  Full Text »  |  PDF »

Myosin II contributes to the posterior contraction and the anterior extension during the retraction phase in migrating Dictyostelium cells.

K. S. K. Uchida, T. Kitanishi-Yumura, and S. Yumura (2003)
J. Cell Sci. 116, 51-60
 |  Abstract »  |  Full Text »  |  PDF »

AUTONOMOUS REORGANIZATION OF FORAMINIFERAN RETICULOPODIA.

J. L. Travis, E. A. Welnhofer, and D. D. Orokos (2002)
Journal of Foraminiferal Research 32, 425-433
 |  Abstract »  |  Full Text »  |  PDF »

Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels.

R. K. Sawhney and J. Howard (2002)
J. Cell Biol. 157, 1083-1092
 |  Abstract »  |  Full Text »  |  PDF »

The NH2-terminal peptide of {alpha}-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo.

B. Hinz, G. Gabbiani, and C. Chaponnier (2002)
J. Cell Biol. 157, 657-663
 |  Abstract »  |  Full Text »  |  PDF »

A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis.

W. B. Kiosses, J. Hood, S. Yang, M. E. Gerritsen, D. A. Cheresh, N. Alderson, and M. A. Schwartz (2002)
Circ. Res. 90, 697-702
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles of Frontal and Rear Cell-Substrate Adhesions in Fibroblast Migration.

S. Munevar, Y.-l. Wang, and M. Dembo (2001)
Mol. Biol. Cell 12, 3947-3954
 |  Abstract »  |  Full Text »  |  PDF »

Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture.

H. M. LANGEVIN, D. L. CHURCHILL, and M. J. CIPOLLA (2001)
FASEB J 15, 2275-2282
 |  Abstract »  |  Full Text »  |  PDF »

Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation.

A. D. Verin, A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J. G. N. Garcia (2001)
Am J Physiol Lung Cell Mol Physiol 281, L565-L574
 |  Abstract »  |  Full Text »  |  PDF »

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity.

B. Hinz, G. Celetta, J. J. Tomasek, G. Gabbiani, and C. Chaponnier (2001)
Mol. Biol. Cell 12, 2730-2741
 |  Abstract »  |  Full Text »  |  PDF »

Cytochalasin D induces edema formation and lowering of interstitial fluid pressure in rat dermis.

A. Berg, K. Rubin, and R. K. Reed (2001)
Am J Physiol Heart Circ Physiol 281, H7-H13
 |  Abstract »  |  Full Text »  |  PDF »

Focal Contacts as Mechanosensors: Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism.

D. Riveline, E. Zamir, N. Q. Balaban, U. S. Schwarz, T. Ishizaki, S. Narumiya, Z. Kam, B. Geiger, and A. D. Bershadsky (2001)
J. Cell Biol. 153, 1175-1186
 |  Abstract »  |  Full Text »  |  PDF »

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts.

K. A. Beningo, M. Dembo, I. Kaverina, J. V. Small, and Y.-l. Wang (2001)
J. Cell Biol. 153, 881-888
 |  Abstract »  |  Full Text »  |  PDF »

p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion.

I Grosheva, M Shtutman, M Elbaum, and A. Bershadsky (2001)
J. Cell Sci. 114, 695-707
 |  Abstract »  |  PDF »

Preferential role of intracellular Ca2+ stores in regulation of isometric force in NIH 3T3 fibroblast fibres.

K. Nobe, H. Nobe, K. Obara, and R. J Paul (2000)
J. Physiol. 529, 669-679
 |  Abstract »  |  Full Text »  |  PDF »

Agonist-induced isometric contraction of smooth muscle cell-populated collagen gel fiber.

K. Oishi, Y. Itoh, Y. Isshiki, C. Kai, Y. Takeda, K. Yamaura, H. Takano-Ohmuro, and M. K. Uchida (2000)
Am J Physiol Cell Physiol 279, C1432-C1442
 |  Abstract »  |  Full Text »  |  PDF »

Acting like Actin: The Dynamics of the Nematode Major Sperm Protein (Msp) Cytoskeleton Indicate a Push-Pull Mechanism for Amoeboid Cell Motility.

T. M. Roberts and M. Stewart (2000)
J. Cell Biol. 149, 7-12
 |  Full Text »  |  PDF »

Glucocorticoid-induced contractility and F-actin content of human lung fibroblasts in three-dimensional culture.

H. Miki, T. Mio, S. Nagai, Y. Hoshino, T. Tsutsumi, T. Mikuniya, and T. Izumi (2000)
Am J Physiol Lung Cell Mol Physiol 278, L13-L18
 |  Abstract »  |  Full Text »  |  PDF »

Keratocytes Pull with Similar Forces on Their Dorsal and Ventral Surfaces.

C. G. Galbraith and M. P. Sheetz (1999)
J. Cell Biol. 147, 1313-1324
 |  Abstract »  |  Full Text »  |  PDF »

A Role for P21-Activated Kinase in Endothelial Cell Migration.

W. B. Kiosses, R. H. Daniels, C. Otey, G. M. Bokoch, and M. A. Schwartz (1999)
J. Cell Biol. 147, 831-844
 |  Abstract »  |  Full Text »  |  PDF »

Keratocytes Generate Traction Forces in Two Phases.

K. Burton, J. H. Park, and D. L. Taylor (1999)
Mol. Biol. Cell 10, 3745-3769
 |  Abstract »  |  Full Text »

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions.

D. M. Helfman, E. T. Levy, C. Berthier, M. Shtutman, D. Riveline, I. Grosheva, A. Lachish-Zalait, M. Elbaum, and A. D. Bershadsky (1999)
Mol. Biol. Cell 10, 3097-3112
 |  Abstract »  |  Full Text »

INTERSTITIAL CELLULAR AND MATRIX RESTORATION OF CARDIAC VALVES AFTERCRYOPRESERVATION.

R. H. Messier Jr, B. L. Bass, P. W. Domkowski, and R. A. Hopkins (1999)
J. Thorac. Cardiovasc. Surg. 118, 36-49
 |  Abstract »  |  Full Text »  |  PDF »

Separation of Propulsive and Adhesive Traction Stresses in Locomoting Keratocytes.

T. Oliver, M. Dembo, and K. Jacobson (1999)
J. Cell Biol. 145, 589-604
 |  Abstract »  |  Full Text »  |  PDF »

How cells (might) sense microgravity.

D. INGBER (1999)
FASEB J 13, 3-15
 |  Abstract »  |  Full Text »  |  PDF »

Vanadate and the Absence of Myofibroblasts in Wound Contraction.

H. P. Ehrlich, K. A. Keefer, R. L. Myers, and A. Passaniti (1999)
Arch Surg 134, 494-501
 |  Abstract »  |  Full Text »  |  PDF »

Radixin Is Involved in Lamellipodial Stability during Nerve Growth Cone Motility.

L. Castelo and D. G. Jay (1999)
Mol. Biol. Cell 10, 1511-1520
 |  Abstract »  |  Full Text »

High Resolution Detection of Mechanical Forces Exerted by Locomoting Fibroblasts on the Substrate.

R. J. Pelham Jr. and Y.-l. Wang (1999)
Mol. Biol. Cell 10, 935-945
 |  Abstract »  |  Full Text »

Cell adhesion force microscopy.

G. Sagvolden, I. Giaever, E. O. Pettersen, and J. Feder (1999)
PNAS 96, 471-476
 |  Abstract »  |  Full Text »  |  PDF »

Effects of H-7 on the Iris and Ciliary Muscle in Monkeys.

B. Tian, C. Millar, P. L. Kaufman, A. Bershadsky, E. Becker, and B. Geiger (1998)
Arch Ophthalmol 116, 1070-1077
 |  Abstract »  |  Full Text »  |  PDF »

Evolution and clinical implications of the myofibroblast concept.

G. Gabbiani (1998)
Cardiovasc Res 38, 545-548
 |  Full Text »  |  PDF »

Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells?.

J. Pourati, A. Maniotis, D. Spiegel, J. L. Schaffer, J. P. Butler, J. J. Fredberg, D. E. Ingber, D. Stamenovic, and N. Wang (1998)
Am J Physiol Cell Physiol 274, C1283-C1289
 |  Abstract »  |  Full Text »  |  PDF »

Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.

C. Baudoin, M.-J. Goumans, C. Mummery, and A. Sonnenberg (1998)
Genes & Dev. 12, 1202-1216
 |  Abstract »  |  Full Text »

beta 1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function.

S. F. Retta, F. Balzac, P. Ferraris, A. M. Belkin, R. Fässler, M. J. Humphries, G. De Leo, L. Silengo, and G. Tarone (1998)
Mol. Biol. Cell 9, 715-731
 |  Abstract »  |  Full Text »

Muscle {beta}1D Integrin Reinforces the Cytoskeleton-Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing.

A. M. Belkin, S. F. Retta, O. Y. Pletjushkina, F. Balzac, L. Silengo, R. Fassler, V. E. Koteliansky, K. Burridge, and G. Tarone (1997)
J. Cell Biol. 139, 1583-1595
 |  Abstract »  |  Full Text »  |  PDF »

Cell locomotion and focal adhesions are regulated by substrate flexibility.

R. J. Pelham Jr. and Y.-l. Wang (1997)
PNAS 94, 13661-13665
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium.

A. M. Malek, I. W. Lee, S. L. Alper, and S. Izumo (1997)
Am J Physiol Cell Physiol 273, C1764-C1774
 |  Abstract »  |  Full Text »  |  PDF »

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells.

C. Zhong, M. S. Kinch, and K. Burridge (1997)
Mol. Biol. Cell 8, 2329-2344
 |  Abstract »  |  Full Text »

Contractile Responses of Cultured Bovine Retinal Pericytes to Angiotensin II.

T. Matsugi, Q. Chen, and D. R. Anderson (1997)
Arch Ophthalmol 115, 1281-1285
 |  Abstract »  |  PDF »

Identification of Novel Graded Polarity Actin Filament Bundles in Locomoting Heart Fibroblasts: Implications for the Generation of Motile Force.

L. P. Cramer, M. Siebert, and T. J. Mitchison (1997)
J. Cell Biol. 136, 1287-1305
 |  Abstract »  |  Full Text »  |  PDF »

Time scale dependent viscoelastic and contractile regimes in fibroblasts probed by microplate manipulation.

O Thoumine and A Ott (1997)
J. Cell Sci. 110, 2109-2116
 |  Abstract »  |  PDF »

A Comparison of the Ability of Intra-oral and Extra-oral Fibroblasts to Stimulate Extracellular Matrix Reorganization in a Model of Wound Contraction.

P. Stephens, K.J. Davies, T. Al-Khateeb, J.P. Shepherd, and D.W. Thomas (1996)
Journal of Dental Research 75, 1358-1364
 |  Abstract »  |  PDF »

On the possible role of cytoskeletal filamentous networks in intracellular signaling: an approach based on percolation.

G Forgacs (1995)
J. Cell Sci. 108, 2131-2143
 |  PDF »

A methodology for the systematic and quantitative study of cell contact guidance in oriented collagen gels. Correlation of fibroblast orientation and gel birefringence.

S Guido and R. Tranquillo (1993)
J. Cell Sci. 105, 317-331
 |  Abstract »  |  PDF »

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton.

D. Ingber (1993)
J. Cell Sci. 104, 613-627
 |  PDF »

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape.

J. R. Sims, S. Karp, and D. E. Ingber (1992)
J. Cell Sci. 103, 1215-1222
 |  Abstract »  |  PDF »

Tooth Movement.

Z. Davidovitch (1991)
Critical Reviews in Oral Biology & Medicine 2, 411-450
 |  Abstract »  |  Full Text »  |  PDF »

Stretch-inactivated ion channels coexist with stretch-activated ion channels.

C. Morris and W. Sigurdson (1989)
Science 243, 807-809
 |  Abstract »  |  PDF »

Cortical flow in animal cells.

D Bray and J. White (1988)
Science 239, 883-888
 |  Abstract »  |  PDF »

Marching at the front and dragging behind: differential {alpha}V{beta}3-integrin turnover regulates focal adhesion behavior.

C. Ballestrem, B. Hinz, B. A. Imhof, and B. Wehrle-Haller (2001)
J. Cell Biol. 155, 1319-1332
 |  Abstract »  |  Full Text »  |  PDF »

Cell prestress. II. Contribution of microtubules.

D. Stamenovic, S. M. Mijailovich, I. M. Tolic-Norrelykke, J. Chen, and N. Wang (2002)
Am J Physiol Cell Physiol 282, C617-C624
 |  Abstract »  |  Full Text »  |  PDF »

Redox Regulation of Vascular Smooth Muscle Cell Differentiation.

B. Su, S. Mitra, H. Gregg, S. Flavahan, M. A. Chotani, K. R. Clark, P. J. Goldschmidt-Clermont, and N. A. Flavahan (2001)
Circ. Res. 89, 39-46
 |  Abstract »  |  Full Text »  |  PDF »

A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis.

W. B. Kiosses, J. Hood, S. Yang, M. E. Gerritsen, D. A. Cheresh, N. Alderson, and M. A. Schwartz (2002)
Circ. Res. 90, 697-702
 |  Abstract »  |  Full Text »  |  PDF »

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