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Science 11 April 1980:
Vol. 208. no. 4440, pp. 145 - 151
DOI: 10.1126/science.7361112
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Articles

Science, Vol 208, Issue 4440, 145-151
Copyright © 1980 by American Association for the Advancement of Science

articles

Blue light and bilirubin excretion

AF McDonagh, LA Palma, and DA Lightner

Blue light converts bilirubin in the skin of jaundiced rats to metastable geometric isomers that are transported in blood and excreted in bile. The same reaction probably occurs in jaundiced babies exposed to light, particularly during treatment with phototherapy. Excretion of unisomerized bilirubin is prevented by intramolecular hydrogen bonding, and the pigment has to be metabolized to more polar derivatives to be excreted efficiently.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Photoisomers: Obfuscating Factors in Clinical Peroxidase Measurements of Unbound Bilirubin?.
A. F. McDonagh, H. J. Vreman, R. J. Wong, and D. K. Stevenson (2009)
Pediatrics 123, 67-76
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Effect of Neonatal Phototherapy on Melanocytic Nevus Count in Children.
E. Matichard, A. Le Henanff, A. Sanders, J. Leguyadec, B. Crickx, and V. Descamps (2006)
Arch Dermatol 142, 1599-1604
   Abstract »    Full Text »    PDF »
Transcutaneous Bilirubinometry: III. Dermal Bilirubin Kinetics Under Green and Blue Light Phototherapy.
T. Hegyi, M. Graff, V. Zapanta, M. Hiatt, and T. R. C. Sisson (1986)
Arch Pediatr Adolesc Med 140, 994-997
   Abstract »    PDF »
Efficacy and Safety of the "Integral" Phototherapy for Neonatal Hyperbilirubinemia: Results of a Follow-up at 6 Years of Age.
B. Granati, G. Largajolli, F.F. Rubaltelli, P. Pollazzon, M. Bottos, and E. Sartori (1984)
Clinical Pediatrics 23, 483-486
   Abstract »    PDF »
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model.
G. Drummond and A Kappas (1982)
Science 217, 1250-1252
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Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin.
D. Hakanson and W. Bergstrom (1981)
Science 214, 807-809
   Abstract »    PDF »
Phototherapy for Primary Biliary Cirrhosis.
S. M. Perlstein (1981)
Arch Dermatol 117, 608
   Abstract »    PDF »
Affinity of Human Serum Albumin for Bilirubin Varies with Albumin Concentration and Buffer Composition. RESULTS OF A NOVEL ULTRAFILTRATION METHOD.
R. A. Weisiger, J. D. Ostrow, R. K. Koehler, C. C. Webster, P. Mukerjee, L. Pascolo, and C. Tiribelli (2001)
J. Biol. Chem. 276, 29953-29960
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)