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Science 4 April 1980:
Vol. 208. no. 4439, pp. 64 - 66
DOI: 10.1126/science.7361107
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Articles

Science, Vol 208, Issue 4439, 64-66
Copyright © 1980 by American Association for the Advancement of Science

articles

Diphenylhydantoin: pre- and postnatal administration alters diazepam binding in developing rat cerebral cortex

DW Gallager and P Mallorga

Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)