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Science 28 March 1980:
Vol. 207. no. 4438, pp. 1471 - 1473
DOI: 10.1126/science.7361097
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Articles

Science, Vol 207, Issue 4438, 1471-1473
Copyright © 1980 by American Association for the Advancement of Science

articles

Successful culture of rat embryos on human serum: use in the detection of teratogens

CL Chatot, NW Klein, J Piatek, and LJ Pierro

Growth of head-fold-stage rat embryos cultured with human serum for 48 hours was enhanced by supplementation with glucose. Embryo growth (protein and DNA contents) varied with the source of the serum. Serum from 16 of 19 untreated subjects produced normal embryos. Serum from five subjects undergoing cancer chemotherapy and six subjects receiving anticonvulsants was either lethal or teratogenic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos.
N. Klein, J. Plenefisch, S. Carey, W. Fredrickson, G. Sackett, T. Burbacher, and R. Parker (1982)
Science 215, 66-69
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Science. ISSN 0036-8075 (print), 1095-9203 (online)