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Science 28 March 1980:
Vol. 207. no. 4438, pp. 1469 - 1470
DOI: 10.1126/science.6767272
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Articles

Science, Vol 207, Issue 4438, 1469-1470
Copyright © 1980 by American Association for the Advancement of Science

articles

Cytochrome p-450: localization in rabbit lung

CJ Serabjit-Singh, CR Wolf, RM Philpot, and CG Plopper

Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foriegn compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.


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