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Science 14 March 1980:
Vol. 207. no. 4436, pp. 1222 - 1224
DOI: 10.1126/science.6243788
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Articles
Science, Vol 207, Issue 4436, 1222-1224
Copyright © 1980 by American Association for the Advancement of Science
Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus
M Oskarsson,
WL McClements,
DG Blair,
JV Maizel,
and
GF Vande Woude
A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balb/c genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage lambda. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive.
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