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Science 7 March 1980:
Vol. 207. no. 4435, pp. 1081 - 1083
DOI: 10.1126/science.6986652
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Articles

Science, Vol 207, Issue 4435, 1081-1083
Copyright © 1980 by American Association for the Advancement of Science

articles

Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus

M van Houten, BI Posner, BM Kopriwa, and Brawer JR

Specific binding sites for blood-borne insulin were determined to be selectively localized on axons and axon terminals in the external median eminence and the hypothalamic arcuate nucleus by means of quantitative fine structural radioautography. This localization suggests that discrete populations of hypothalamic nerve terminals are potential targets for the direct effects of insulin and that insulin may act through synaptic mechanisms to influence hypothalamic circuits regulating energy balance and hypophyseal function.


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