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Science 22 February 1980:
Vol. 207. no. 4433, pp. 902 - 904
DOI: 10.1126/science.6766565
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Articles

Science, Vol 207, Issue 4433, 902-904
Copyright © 1980 by American Association for the Advancement of Science

articles

Sparing of the brain in neonatal undernutrition: amino acid transport and incorporation into brain and muscle

LS Freedman, S Samuels, I Fish, SA Schwartz, B Lange, M Katz, and L Morgano

Rates of tyrosine and lysine transport and incorporation into protein were measured in control and undernourished weanling rats. Undernutrition was induced by feeding lactating dams a low protein diet (12 percent casein) from birth to day 21. At weaning, body and brain weights of undernourished rats were 50 percent and 88 percent, respectively, of control values. Lysine and tyrosine transport rates into skeletal muscle were reduced by over 75 percent, more than twice the reduction seen in brain. Rates of amino acid incorporation into muscle protein were reduced by approximately 50 percent; the change in rate of incorporation into brain protein was not statistically significant. These data indicate that, in spite of marked retardation of amino acid transport into brain, the brain seems fully capable of maintaining normal rates of protein synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats.
P. C. Even, E. Bertin, M.-N. Gangnerau, S. Roseau, D. Tome, and B. Portha (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R751-R759
   Abstract »    Full Text »    PDF »
Placenta as a Link between Amino Acids, Insulin-IGF Axis, and Low Birth Weight: Evidence from Twin Studies.
R. Bajoria, S. R. Sooranna, S. Ward, and M. Hancock (2002)
J. Clin. Endocrinol. Metab. 87, 308-315
   Abstract »    Full Text »    PDF »
Selective expression of the large neutral amino acid transporter at the blood-brain barrier.
R. J. Boado, J. Y. Li, M. Nagaya, C. Zhang, and W. M. Pardridge (1999)
PNAS 96, 12079-12084
   Abstract »    Full Text »    PDF »


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