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Science 22 February 1980:
Vol. 207. no. 4433, pp. 896 - 898
DOI: 10.1126/science.6444467
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Articles

Science, Vol 207, Issue 4433, 896-898
Copyright © 1980 by American Association for the Advancement of Science

articles

Circadian rhythms in Neurospora crassa: oligomycin-resistant mutations affect periodicity

C Diekmann and S Brody

Nuclear mutations conferring resistance to oligomycin, a mitochondrial inhibitor, shorten the period of the circadian conidiation rhythm of Neurospora crassa from the normal 21.5 hours to 18 to 19 hours and slow the linear growth rate by 30 percent. These olir mutations map very close to frq, a locus at which mutations affecting periodicity have been previously obtained. The possibilities are discussed that mitochondria are involved in circadian rhythm generation and that certain period-length mutations affect mitochondrial functions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic and Molecular Analysis of Biological Rhythms.
J. C. Hall and M. Rosbash (1987)
J Biol Rhythms 2, 153-178
   PDF »
Phase Shifting of the Circadian Conidiation Rhythm in Neurospora crassa by Calmodulin Antagonists.
H. Nakashima (1986)
J Biol Rhythms 1, 163-169
   Abstract »    PDF »
Regulation of circadian rhythmicity.
J. Takahashi and M Zatz (1982)
Science 217, 1104-1111
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)