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Science 8 February 1980:
Vol. 207. no. 4431, pp. 647 - 649
DOI: 10.1126/science.6928071
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Articles

Science, Vol 207, Issue 4431, 647-649
Copyright © 1980 by American Association for the Advancement of Science

articles

Hemoglobin switching: a cellular model

BP Alter and SC Goff

Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Erythroid differentiation of clonal Rauscher erythroleukemia cells in response to erythropoietin or dimethyl sulfoxide.
A. Sytkowski, A. Salvado, G. Smith, C. McIntyre, and N. deBoth (1980)
Science 210, 74-76
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