Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 February 1980:
Vol. 207. no. 4431, pp. 645 - 647
DOI: 10.1126/science.6101510
Prev | Table of Contents | Next

Articles

Science, Vol 207, Issue 4431, 645-647
Copyright © 1980 by American Association for the Advancement of Science

articles

beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system

A Maggi, DC U'Prichard, and SJ Enna

Incubation of rat cerebral cortical slices with the beta-adrenergic agonist isoproterenol causes an increase in alpha 2-adrenergic receptor binding in addition to a decrease in beta-adrenergic receptor binding. The effects are rapid and reversible, show a parallel time course, and are blocked by sotalol, a beta-adrenergic receptor antagonist. The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}2C-Adrenergic Receptors Exhibit Enhanced Surface Expression and Signaling upon Association with beta2-Adrenergic Receptors.
S. C. Prinster, T. G. Holmqvist, and R. A. Hall (2006)
J. Pharmacol. Exp. Ther. 318, 974-981
   Abstract »    Full Text »    PDF »
Network integration of the adrenergic system in cardiac hypertrophy.
L. Barki-Harrington, C. Perrino, and H. A Rockman (2004)
Cardiovasc Res 63, 391-402
   Abstract »    Full Text »    PDF »
Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons.
L. F. Agnati, S. Ferre, C. Lluis, R. Franco, and K. Fuxe (2003)
Pharmacol. Rev. 55, 509-550
   Abstract »    Full Text »    PDF »
Heterodimerization of alpha 2A- and beta 1-Adrenergic Receptors.
J. Xu, J. He, A. M. Castleberry, S. Balasubramanian, A. G. Lau, and R. A. Hall (2003)
J. Biol. Chem. 278, 10770-10777
   Abstract »    Full Text »    PDF »
Autonomic Nervous System Abnormalities and Allergy.
M. KALINER, J. H. SHELHAMER, P. B. DAVIS, L. J. SMITH, and J. C. VENTER (1982)
Ann Intern Med 96, 349-357
   Abstract »    PDF »
Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression.
D. S. Charney, D. B. Menkes, and G. R. Heninger (1981)
Arch Gen Psychiatry 38, 1160-1180
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)