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Science 1 February 1980:
Vol. 207. no. 4430, pp. 540 - 541
DOI: 10.1126/science.6243416
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Articles

Science, Vol 207, Issue 4430, 540-541
Copyright © 1980 by American Association for the Advancement of Science

articles

Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis virus from interferon-treated cells

RK Maheshwari, FT Jay, and RM Friedman

A 200-fold inhibition in the titer of infectious vesicular stomatitis virus (VSV) was produced in cultures of Ly cells treated with 30 reference units of interferon per milliliter. Virus particle production, as measured by VSV particle-associated transcriptase, or nucleocapsid protein was inhibited by a maximum of tenfold. The glycoprotein and membrane protein content was reduced in VSV derived from interferon-treated cells. Thus interferon-treated cells may have produced VSV particles with low infectivity, which may be related to the reduced amount of glycoprotein incorporated into such particles. These findings resemble those reported in interferon-treated cells infected with murine leukemia viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High Resistance of Human Parainfluenza Type 2 Virus Protein-Expressing Cells to the Antiviral and Anti-Cell Proliferative Activities of Alpha/Beta Interferons: Cysteine-Rich V-Specific Domain Is Required for High Resistance to the Interferons.
M. Nishio, M. Tsurudome, M. Ito, M. Kawano, H. Komada, and Y. Ito (2001)
J. Virol. 75, 9165-9176
   Abstract »    Full Text »    PDF »
Tunicamycin enhances the antiviral and anticellular activity of interferon.
R. Maheshwari, T Sreevalsan, R. Silverman, J Hay, and R. Friedman (1983)
Science 219, 1339-1341
   Abstract »    PDF »
Interferon-resistant cell line lacks fatty acid cyclooxygenase activity.
K. Chandrabose, P Cuatrecasas, R Pottathil, and D. Lang (1981)
Science 212, 329-331
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)