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Science 1 February 1980:
Vol. 207. no. 4430, pp. 486 - 493
DOI: 10.1126/science.7352255
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Articles

Science, Vol 207, Issue 4430, 486-493
Copyright © 1980 by American Association for the Advancement of Science

articles

Disorders of human hemoglobin

A Bank, JG Mears, and F Ramirez

Studies of the human hemoglobin system have provided new insights into the regulation of expression of a group of linked human genes, the gamma-delta-beta-globin gene complex in man. In particular, the thalassemia syndromes and related disorders of man are inherited anemias that provide mutations for the study of the regulation of globin gene expression. New methods, including restriction enzyme analysis and cloning of cellular DNA, have made it feasible to define more precisely the structure and organization of the globin genes in cellular DNA. Deletions of specific globin gene fragments have already been found in certain of these disorders and have been applied in prenatal diagnosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of human fetal hemoglobin: new players, new complexities.
A. Bank (2006)
Blood 107, 435-443
   Abstract »    Full Text »    PDF »
Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching.
D. O'Neill, J. Yang, H. Erdjument-Bromage, K. Bornschlegel, P. Tempst, and A. Bank (1999)
PNAS 96, 349-354
   Abstract »    Full Text »    PDF »
Thalassemias: models of genetic diseases.
G. Kolata (1980)
Science 210, 300-302
   PDF »


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