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Science 25 January 1980:
Vol. 207. no. 4429, pp. 373 - 378
DOI: 10.1126/science.6153132
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Articles

Science, Vol 207, Issue 4429, 373-378
Copyright © 1980 by American Association for the Advancement of Science

articles

Synthesis, transport, and release of posterior pituitary hormones

MJ Brownstein, JT Russell, and H Gainer

Vasopressin and oxytocin are made and released by neurons of the hypothalamo-neurohypophysial system. Pulse labeling these neurons with radioactive amino acid indicates that the two hormones and their respective neurophysin carrier proteins are synthesized as parts of separate precursor proteins. The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon.


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