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Science 18 January 1980:
Vol. 207. no. 4428, pp. 329 - 331
DOI: 10.1126/science.7188649
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Articles

Science, Vol 207, Issue 4428, 329-331
Copyright © 1980 by American Association for the Advancement of Science

articles

Interchangeability of stress and amphetamine in sensitization

SM Antelman, AJ Eichler, CA Black, and D Kocan

In view of similarities between the behavioral, biochemical, and electrophysiological effects of amphetamine and stress, we tested the hypothesis that presentation of a stressor, mild tail pressure, can sensitize an animal to the later effects of amphetamine, and vice versa. Our findings supported this hypothesis and suggest that amphetamine and at least some stressors may be interchangeable in their ability to induce a sensitization. The data raise the possibility that stress might be a common variable contributing to both amphetamine psychosis and some forms of schizophrenia.


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