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Science 18 January 1980:
Vol. 207. no. 4428, pp. 319 - 321
DOI: 10.1126/science.7350664
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Articles

Science, Vol 207, Issue 4428, 319-321
Copyright © 1980 by American Association for the Advancement of Science

articles

Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose

HG Zimmer, H Ibel, G Steinkopff, and G Korb

Continuous intravenous infusion of ribose (200 milligrams per kilogram per hour) for 24 hours induced a marked stimulation of cardiac adenine nucleotide biosynthesis in unanesthetized and unrestrained rats that had been treated with isoproterenol subcutaneously (25 milligrams per kilogram). The diminution of adenine nucleotides characteristic for the action of high doses of isoproterenol was entirely prevented, and the incidence of the isoproterenol-induced myocardial cell damage was significantly reduced when ribose was administered. These results support the view that depletion of adenine nucleotides is involved in the development of cardiac necrosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ribose intervention in the cardiac pentose phosphate pathway is not species-specific.
H. Zimmer, H Ibel, U Suchner, and H Schad (1984)
Science 223, 712-714
   Abstract »    PDF »
Normalization of depressed heart function in rats by ribose.
H. Zimmer (1983)
Science 220, 81-82
   Abstract »    PDF »


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