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Science 18 January 1980:
Vol. 207. no. 4428, pp. 313 - 315
DOI: 10.1126/science.7350662
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Articles

Science, Vol 207, Issue 4428, 313-315
Copyright © 1980 by American Association for the Advancement of Science

articles

Retina-dependent activation by apomorphine of metabolic activity in the superficial layer of the superior colliculus

J McCulloch, HE Savaki, MC McCulloch, and L Sokoloff

Studies of the effect of the dopamine agonist apomorphine on local cerebral glucose utilization by means of the carbon-14-labeled deoxyglucose method demonstrate a dose-dependent metabolic activation in the superficial layer of the superior colliculus in the rat. Apomorphine stimulated glucose utilization in a number of other cerebral structures, but only the effect in the superficial layer of the superior colliculus depended on an intact retinal input. This effect was present with the animal in the light or in the dark, but was abolished by enucleation, which left the effects in other cerebral structures unimpaired. Activation of the superificial layer of the superior colliculus appears, therefore, to be secondary to an action of apomorphine on dopaminergic systems within the retina.


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Altered thalamic response to levodopa in Parkinson's patients with dopa-induced dyskinesias.
T. Hershey, K. J. Black, M. K. Stambuk, J. L. Carl, L. A. McGee-Minnich, and J. S. Perlmutter (1998)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)