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Science 18 January 1980:
Vol. 207. no. 4428, pp. 311 - 313
DOI: 10.1126/science.7350661
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Articles

Science, Vol 207, Issue 4428, 311-313
Copyright © 1980 by American Association for the Advancement of Science

articles

Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether

BT Mossman, JE Craighead, and BV MacPherson

The epithelium of the hamster trachea in organ culture undergoes hyperplasia and squamous metaplasia after exposure to the amphibole types of asbestos, crocidolite and amosite. These changes are inhibited when the synthetic vitamin A analog, retinyl methyl ether, is incorporated into the culture medium. These findings suggest a possible use for retinoids in the prevention and treatment of respiratory tract disease associated with environmental exposure to asbestos.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos.
C. B. Manning, T. Sabo-Attwood, R. F. Robledo, M. B. MacPherson, M. Rincon, P. Vacek, D. Hemenway, D. J. Taatjes, P. J. Lee, and B. T. Mossman (2008)
Am. J. Respir. Cell Mol. Biol. 38, 618-626
   Abstract »    Full Text »    PDF »
Oxidants and Signaling by Mitogen-Activated Protein Kinases in Lung Epithelium.
B. T. Mossman, K. M. Lounsbury, and S. P. Reddy (2006)
Am. J. Respir. Cell Mol. Biol. 34, 666-669
   Abstract »    Full Text »    PDF »
Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation Are Altered in Myeloperoxidase-Null Mice.
A. Haegens, A. van der Vliet, K. J. Butnor, N. Heintz, D. Taatjes, D. Hemenway, P. Vacek, B. A. Freeman, S. L. Hazen, M. L. Brennan, et al. (2005)
Cancer Res. 65, 9670-9677
   Abstract »    Full Text »    PDF »
Increased Localization and Substrate Activation of Protein Kinase C{delta} in Lung Epithelial Cells following Exposure to Asbestos.
K. M. Lounsbury, M. Stern, D. Taatjes, S. Jaken, and B. T. Mossman (2002)
Am. J. Pathol. 160, 1991-2000
   Abstract »    Full Text »    PDF »
In Vitro Studies of Mechanisms of Lung Injury in the Rodent*1.
L. A. Cohn and K. B. Adler (1991)
Toxicol Pathol 19, 419-427
   Abstract »    PDF »


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