Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 January 1980:
Vol. 207. no. 4427, pp. 205 - 207
DOI: 10.1126/science.7350658
Prev | Table of Contents | Next

Articles

Science, Vol 207, Issue 4427, 205-207
Copyright © 1980 by American Association for the Advancement of Science

articles

Prenatal exposure to diazepam alters behavioral development in rats

C Kellogg, D Tervo, J Ison, T Parisi, and RK Miller

Characteristic potentiation of rat locomotion responses and acoustic startle reflexes that normally appear in the third postnatal week was absent in rats exposed to diazepam during the third week of gestation. Loss of these behaviors suggests a long-term effect that may result from changes in cellular development. Tissue undergoing neuronal differentation may be especially sensitive to drugs that act on the central nervous system, and the period in which differentiation occurs is perhaps critical for the induction of changes that are later expressed as altered behavior.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Electrophysiological Studies of Visual Word Perception, Lexical Organization, and Semantic Processing: A Tutorial Review.
S. Bentin (1989)
Language and Speech 32, 205-220
   Abstract »    PDF »
Concurrent Use of Behavioral/Functional Testing in Existing Reproductive and Developmental Toxicity Screens: Practical Considerations.
E. A. Lochry (1987)
International Journal of Toxicology 6, 433-439
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)