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Science 11 January 1980:
Vol. 207. no. 4427, pp. 193 - 195
DOI: 10.1126/science.7350655
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Articles

Science, Vol 207, Issue 4427, 193-195
Copyright © 1980 by American Association for the Advancement of Science

articles

Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis

FA Fuhrman, GJ Fuhrman, YH Kim, LA Pavelka, and HS Mosher

A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Isoguanosine: isolation from an animal.
F. Fuhrman, G. Fuhrman, R. Nachman, and H. Mosher (1981)
Science 212, 557-558
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)