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Science 4 January 1980:
Vol. 207. no. 4426, pp. 84 - 86
DOI: 10.1126/science.7350645
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Articles

Science, Vol 207, Issue 4426, 84-86
Copyright © 1980 by American Association for the Advancement of Science

articles

Entry of opioid peptides into the central nervous system

SI Rapoport, WA Klee, KD Pettigrew, and K Ohno

Cerebrovascular permeability of four modified opioid peptides--[D-Ala2]methionine enkephalin amide, beta-[D-Ala62,14C-Homoarg69]lipotropin 61 -69, alpha-[D-Ala2,14C-Homoarg9]endorphin, and beta-[D-Ala2,14C-Homoarg]endorphin--ranged from 1.4 to 3.9 X 10(-6) centimeters per second in brain regions of the conscous rat. These significant permeabilities should allow the peptides to fill the extracellular brain space with a half time of 3 to 11 minutes, as a result of a step increase in plasma concentration of unbound peptide.


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Adrenocorticotropic Hormone, {beta}-Lipotropin, and Endorphin-Related Peptides in Health and Disease.
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