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Science 4 January 1980:
Vol. 207. no. 4426, pp. 75 - 76
DOI: 10.1126/science.6243189
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Articles

Science, Vol 207, Issue 4426, 75-76
Copyright © 1980 by American Association for the Advancement of Science

articles

Antibodies to cerebroside sulfate inhibit the effects of morphine and beta-endorphin

FB Craves, B Zalc, L Leybin, N Baumann, and HH Loh

Morphine and beta-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and beta-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sulfatide from the Pig Jejunum Brush Border Epithelial Cell Surface Is Involved in Binding of Escherichia coli Enterotoxin b.
E. Rousset, J. Harel, and J. D. Dubreuil (1998)
Infect. Immun. 66, 5650-5658
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