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Science 4 January 1980:
Vol. 207. no. 4426, pp. 71 - 73
DOI: 10.1126/science.6985745
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Articles

Science, Vol 207, Issue 4426, 71-73
Copyright © 1980 by American Association for the Advancement of Science

articles

Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite

N Yoshida, RS Nussenzweig, P Potocnjak, V Nussenzweig, and M Aikawa

Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.


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