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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1423 - 1425
DOI: 10.1126/science.505016
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Articles

Science, Vol 206, Issue 4425, 1423-1425
Copyright © 1979 by American Association for the Advancement of Science

articles

Clonal characteristics of experimentally induced "atherosclerotic" lesions in the hybrid hare

TA Pearson, J Dillman, KJ Williams, JA Wolff, R Adams, K Solez, RH Heptinstall, H Malmros, and N Sternby

The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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K. J. Williams and I. Tabas (2005)
Arterioscler. Thromb. Vasc. Biol. 25, 1536-1540
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Evidence for Oxidative Activation of c-Myc-Dependent Nuclear Signaling in Human Coronary Smooth Muscle Cells and in Early Lesions of Watanabe Heritable Hyperlipidemic Rabbits : Protective Effects of Vitamin E.
F. de Nigris, T. Youssef, S. Ciafre, F. Franconi, V. Anania, G. Condorelli, W. Palinski, and C. Napoli (2000)
Circulation 102, 2111-2117
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Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities.
M. G. Frid, A. A. Aldashev, E. C. Dempsey, and K. R. Stenmark (1997)
Circ. Res. 81, 940-952
   Abstract »    Full Text »
The Intima : Soil for Atherosclerosis and Restenosis.
S. M. Schwartz, D. deBlois, and E. R. M. O'Brien (1995)
Circ. Res. 77, 445-465
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