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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1416 - 1418
DOI: 10.1126/science.505015
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Articles

Science, Vol 206, Issue 4425, 1416-1418
Copyright © 1979 by American Association for the Advancement of Science

articles

A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area

LL Brown, MH Markman, LI Wolfson, B Dvorkin, C Warner, and R Katzman

The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.


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