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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1408 - 1410
DOI: 10.1126/science.228395
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Articles

Science, Vol 206, Issue 4425, 1408-1410
Copyright © 1979 by American Association for the Advancement of Science

articles

Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation

J Larner, G Galasko, K Cheng, AA DePaoli-Roach, L Huang, P Daggy, and J Kellogg

Deproteinized skeletal muscle extracts free of major nucleotides from control and insulin-treated rats were fractionated and assayed for inhibition of protein phosphorylation by cyclic adenosine monophosphate (AMP)-dependent and -independent protein kinases. A differential effect of insulin on a particular fraction was observed on cyclic AMP-dependent protein kinase but not on cyclic AMP-independent protein kinases. This fraction that inhibited cyclic AMP-dependent protein kinase also stimulated glycogen synthase phosphoprotein phosphatase. It is proposed that this fraction may contain a mediator substance generateed in the presence of insulin.


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