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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1407 - 1408
DOI: 10.1126/science.505013
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Articles

Science, Vol 206, Issue 4425, 1407-1408
Copyright © 1979 by American Association for the Advancement of Science

articles

Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle

L Jarett and Seals JR

Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms of Receptor-mediated Transmembrane Communication.
L. Ellis, D.O. Morgan, E. Clauser, M. Edery, S.-M. Jong, L.-H. Wang, R.A. Roth, and W.J. Rutter (1986)
Cold Spring Harb Symp Quant Biol 51, 773-784
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Insulin mediators from rat skeletal muscle have differential effects on insulin-sensitive pathways of intact adipocytes.
L Jarett, E. Wong, S. Macaulay, and J. Smith (1985)
Science 227, 533-535
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Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation.
F Purrello, D. Burnham, and I. Goldfine (1983)
Science 221, 462-464
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Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes.
F Purrello, R Vigneri, G. Clawson, and I. Goldfine (1982)
Science 216, 1005-1007
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Brain pyruvate dehydrogenase: phosphorylation and enzyme activity altered by a training experience.
D. Morgan and A Routtenberg (1981)
Science 214, 470-471
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Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation.
J Larner, G Galasko, K Cheng, A. DePaoli-Roach, L Huang, P Daggy, and J Kellogg (1979)
Science 206, 1408-1410
   Abstract »    PDF »


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