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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1404 - 1406
DOI: 10.1126/science.574316
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Articles

Science, Vol 206, Issue 4425, 1404-1406
Copyright © 1979 by American Association for the Advancement of Science

articles

Chlorpromazine and its metabolites alter polymerization and gelation of actin

E Elias and JL Boyer

Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. G. Sturgill and G. H. Lambert (1997)
Clin. Chem. 43, 1512-1526
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Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani.
R. Pearson, A. Manian, J. Harcus, D Hall, and E. Hewlett (1982)
Science 217, 369-371
   Abstract »    PDF »


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