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Science 14 December 1979:
Vol. 206. no. 4424, pp. 1323 - 1325
DOI: 10.1126/science.390711
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Articles

Science, Vol 206, Issue 4424, 1323-1325
Copyright © 1979 by American Association for the Advancement of Science

articles

Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans

D Baetens, F Malaisse-Lagae, A Perrelet, and L Orci

Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.


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