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Science 14 December 1979:
Vol. 206. no. 4424, pp. 1303 - 1306
DOI: 10.1126/science.117549
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Articles

Science, Vol 206, Issue 4424, 1303-1306
Copyright © 1979 by American Association for the Advancement of Science

articles

Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain

PW Tucker, KB Marcu, N Newell, J Richards, and FR Blattner

The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased Phosphorylation of the Carboxyl-Terminal Domain of RNA Polymerase II and Loading of Polyadenylation and Cotranscriptional Factors Contribute to Regulation of the Ig Heavy Chain mRNA in Plasma Cells.
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J. Immunol. 179, 7663-7673
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Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis.
Y. Zhao, Q. Pan-Hammarstrom, S. Yu, N. Wertz, X. Zhang, N. Li, J. E. Butler, and L. Hammarstrom (2006)
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EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20.
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J. Biol. Chem. 277, 29283-29293
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Somatic Reorganization of Immunoglobulin Genes during Lymphocyte Differentiation.
S. Tonegawa, H. Sakano, R. Maki, A. Traunecker, G. Heinrich, W. Roeder, and Y. Kurosawa (1981)
Cold Spring Harb Symp Quant Biol 45, 839-858
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RNA Processing in Immunoglobulin Gene Expression.
R. Wall, E. Choi, C. Carter, M. Kuehl, and J. Rogers (1981)
Cold Spring Harb Symp Quant Biol 45, 879-885
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Studies on the Nature and Germ-line Stability of DNA Sequences Flanking the Mouse Immunoglobulin Heavy-chain Constant-region Genes.
K. B. Marcu, N. Arnheim, J. Banerji, N. A. Penncavage, P. Seperack, R. Lang, R. Miesfeld, L. Harris, and R. Greenberg (1981)
Cold Spring Harb Symp Quant Biol 45, 899-911
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Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.
P. Tucker, C. Liu, J. Mushinski, and F. Blattner (1980)
Science 209, 1353-1360
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J genes for heavy chain immunoglobulins of mouse.
N Newell, J. Richards, P. Tucker, and F. Blattner (1980)
Science 209, 1128-1132
   Abstract »    PDF »
Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA.
P. Tucker, K. Marcu, J. Slightom, and F. Blattner (1979)
Science 206, 1299-1303
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Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells.
A. Kenter and B. Birshtein (1979)
Science 206, 1307-1309
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