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Science 14 December 1979:
Vol. 206. no. 4424, pp. 1299 - 1303
DOI: 10.1126/science.117548
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Articles

Science, Vol 206, Issue 4424, 1299-1303
Copyright © 1979 by American Association for the Advancement of Science

articles

Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA

PW Tucker, KB Marcu, JL Slightom, and FR Blattner

The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.


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Human immunoglobulin D: genomic sequence of the delta heavy chain.
M. White, A. Shen, C. Word, P. Tucker, and F. Blattner (1985)
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Evolution of Retroviruses from Cellular Movable Genetic Elements.
K. Shimotohno and H. M. Temin (1981)
Cold Spring Harb Symp Quant Biol 45, 719-730
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Studies on the Nature and Germ-line Stability of DNA Sequences Flanking the Mouse Immunoglobulin Heavy-chain Constant-region Genes.
K. B. Marcu, N. Arnheim, J. Banerji, N. A. Penncavage, P. Seperack, R. Lang, R. Miesfeld, L. Harris, and R. Greenberg (1981)
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Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.
P. Tucker, K. Marcu, N Newell, J Richards, and F. Blattner (1979)
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Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells.
A. Kenter and B. Birshtein (1979)
Science 206, 1307-1309
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