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Science 7 December 1979:
Vol. 206. no. 4423, pp. 1184 - 1186
DOI: 10.1126/science.505002
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Articles

Science, Vol 206, Issue 4423, 1184-1186
Copyright © 1979 by American Association for the Advancement of Science

articles

Dopamine-related tetrahydroisoquinolines: significant urinary excretion by alcoholics after alcohol consumption

MA Collins, WP Nijm, GF Borge, G Teas, and C Goldfarb

Concentrations of dopamine-related tetrahydroisoquinolines (salsolinol and O-methylated salsolinol) were significantly higher in the daily urine samples of alcoholic subjects admitted for alcohol detoxification than in the daily urine samples of nonalcoholic control subjects. Salsolinol concentrations in alcoholic subjects appeared to drop to trace (control) values 2 to 3 days after admission, following the disappearance of ethanol and its reactive metabolite acetaldehyde from the blood. These results indicate that physiologically active tetrahydroisoquinolines increase in humans during long-term alcohol consumption, presumably because of acetaldehyde's direct condensation with catecholamines. The presence of these or similar condensation products in the urine could be useful as clinical indicators of prior blood acetaldehyde concentrations in chronic alcoholics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biotransformation of 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a Novel 5-Hydroxytryptamine (5-HT)1A Agonist/5-HT3 Antagonist, in Human Hepatic Cytochrome P450 Enzymes.
K. Minato, R. Suzuki, A. Asagarasu, T. Matsui, and M. Sato (2008)
Drug Metab. Dispos. 36, 831-840
   Abstract »    Full Text »    PDF »
IN VIVO FORMATION OF SALSOLINOL INDUCED BY HIGH ACETALDEHYDE CONCENTRATION IN RAT STRIATUM EMPLOYING MICRODIALYSIS.
M. Jamal, K. Ameno, T. Kubota, S. Ameno, X. Zhang, M. Kumihashi, and I. Ijiri (2003)
Alcohol Alcohol. 38, 197-201
   Abstract »    Full Text »    PDF »
Differential Cell Death Induced by Salsolinol with and without Copper: Possible Role of Reactive Oxygen Species.
H.-J. Kim, Y. Soh, J.-H. Jang, J.-S. Lee, Y. J. Oh, and Y.-J. Surh (2001)
Mol. Pharmacol. 60, 440-449
   Abstract »    Full Text »    PDF »


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