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Science 30 November 1979:
Vol. 206. no. 4422, pp. 1093 - 1095
DOI: 10.1126/science.493996
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Articles

Science, Vol 206, Issue 4422, 1093-1095
Copyright © 1979 by American Association for the Advancement of Science

articles

Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement

RD Freeman and AB Bonds

A marked reduction of binocular cells in striate cortex is found if 4-week-old kittens are visually stimulated monocularly while anesthetized and held in a stereotaxic apparatus. If the kittens are paralyzed and artificially respirated, changes are not found unless an eye is moved mechanically. It appears that eye movement and visual stimulation are necessary conditions for deactivation of binocular connections, but neither is sufficient to induce such changes alone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic Electrical Stimulation of Afferents From One Eye Changes Ocular Dominance of Visual Cortical Neurons in Kittens.
M. Ohshima, Y. Hata, S. Ichisaka, M. Wakita, M. Fukuda, K. Kameyama, and T. Tsumoto (2002)
J Neurophysiol 88, 2147-2151
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Modeling LGN Responses during Free-Viewing: A Possible Role of Microscopic Eye Movements in the Refinement of Cortical Orientation Selectivity.
M. Rucci, G. M. Edelman, and J. Wray (2000)
J. Neurosci. 20, 4708-4720
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Pharmacological induction of use-dependent receptive field modifications in the visual cortex.
J. Greuel, H. Luhmann, and W Singer (1988)
Science 242, 74-77
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Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex.
A Kleinschmidt, M. Bear, and W Singer (1987)
Science 238, 355-358
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A physiological basis for a theory of synapse modification.
M. Bear, L. Cooper, and F. Ebner (1987)
Science 237, 42-48
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Science. ISSN 0036-8075 (print), 1095-9203 (online)