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Science 30 November 1979:
Vol. 206. no. 4422, pp. 1089 - 1091
DOI: 10.1126/science.493994
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Articles

Science, Vol 206, Issue 4422, 1089-1091
Copyright © 1979 by American Association for the Advancement of Science

articles

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter

LP Yotti, CC Chang, and JE Trosko

Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.


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