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Science 2 November 1979:
Vol. 206. no. 4418, pp. 597 - 599
DOI: 10.1126/science.386511
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Articles

Science, Vol 206, Issue 4418, 597-599
Copyright © 1979 by American Association for the Advancement of Science

articles

Antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria

EH Nardin, RS Nussenzweig, IA McGregor, and JH Bryan

Serum samples from 158 West Africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. Antibodies specific for Plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. More than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
EFFECTS OF PERMETHRIN-TREATED BED NETS ON IMMUNITY TO MALARIA IN WESTERN KENYA I. ANTIBODY RESPONSES IN PREGNANT WOMEN AND CORD BLOOD IN AN AREA OF INTENSE MALARIA TRANSMISSION.
S. K. KARIUKI, F. O. TER KUILE, K. WANNEMUEHLER, D. J. TERLOUW, M. S. KOLCZAK, W. A. HAWLEY, P. A. PHILLIPS-HOWARD, A. S. S. ORAGO, B. L. NAHLEN, A. A. LAL, et al. (2003)
Am J Trop Med Hyg 68, 61-67
   Abstract »    Full Text »    PDF »
Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications.
S. Hoffman, C. Oster, C. Plowe, G. Woollett, J. Beier, J. Chulay, R. Wirtz, M. Hollingdale, and M Mugambi (1987)
Science 237, 639-642
   Abstract »    PDF »
Research toward malaria vaccines.
L. Miller, R. Howard, R Carter, M. Good, V Nussenzweig, and R. Nussenzweig (1986)
Science 234, 1349-1356
   Abstract »    PDF »
Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria.
F Zavala, J. Tam, M. Hollingdale, A. Cochrane, I Quakyi, R. Nussenzweig, and V Nussenzweig (1985)
Science 228, 1436-1440
   Abstract »    PDF »
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.
N Yoshida, R. Nussenzweig, P Potocnjak, V Nussenzweig, and M Aikawa (1980)
Science 207, 71-73
   Abstract »    PDF »


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