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Science 2 November 1979:
Vol. 206. no. 4418, pp. 582 - 584
DOI: 10.1126/science.91199
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Articles

Science, Vol 206, Issue 4418, 582-584
Copyright © 1979 by American Association for the Advancement of Science

articles

Circular forms of DNA synthesized by Rous sarcoma virus in vitro

CH Clayman, ET Mosharrafa, DL Anderson, and AJ Feras

Electron microscopic analysis of the DNA product synthesized by detergent-disrupted preparations of Rous sarcoma virus in vitro revealed the presence of several interesting molecular forms including covalently closed circular DNA. The identification of such circular DNA indicates that virions of retroviruses contain all the components necessary to facilitate the complete synthesis of mature forms of viral DNA and therefore provide a useful system to delineate the molecular mechanisms involved in their synthesis.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)