Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 November 1979:
Vol. 206. no. 4418, pp. 528 - 533
DOI: 10.1126/science.386509
Prev | Table of Contents | Next

Articles

Science, Vol 206, Issue 4418, 528-533
Copyright © 1979 by American Association for the Advancement of Science

articles

Heparin: an old drug with a new paradigm

LB Jacques

Recent studies have shown that heparin is a biochemical representative of a distinct class of compounds known as linear anionic polyelectrolytes. Members of this class are mixtures of individual highly negatively charged chains that show a wide spectrum of specific reactions with biologically active proteins. Upon administration, heparin chains enter a cellular pool and effectively prevent thrombosis by increasing the electronegative potential of the vessel wall. Anticoagulant activity is an unusual feature of a few heparin chains and appears to play a minor role in many clinical uses and in physiological and pathological responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Direct Measurement of Unfractionated Heparin Using a Biochemical Assay.
C. H. Mielke JR, C. M. Starr, J. C. Klock, D. Devereaux, M. R. Mielke, D. E. Baker, L. Broemeling, M. Wacksman, J. R. White JR, S. A. Oliver, et al. (1999)
Clinical and Applied Thrombosis/Hemostasis 5, 267-276
   Abstract »    PDF »
Structure and Anticoagulant Activity of Sulfated Fucans. COMPARISON BETWEEN THE REGULAR, REPETITIVE, AND LINEAR FUCANS FROM ECHINODERMS WITH THE MORE HETEROGENEOUS AND BRANCHED POLYMERS FROM BROWN ALGAE.
M. S. Pereira, B. Mulloy, and P. A. S. Mourao (1999)
J. Biol. Chem. 274, 7656-7667
   Abstract »    Full Text »    PDF »
Therapeutic Inhibition of the Complement System.
S. C. Makrides (1998)
Pharmacol. Rev. 50, 59-88
   Abstract »    Full Text »    PDF »
Enzymatic Preparation of Heparin Oligosaccharides Containing Antithrombin III Binding Sites.
T. Toida, R. E. Hileman, A. E. Smith, PetinkaI. Vlahova, and RobertJ. Linhardt (1996)
J. Biol. Chem. 271, 32040-32047
   Abstract »    Full Text »    PDF »
Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm. SULFATED FUCOSE BRANCHES ON THE POLYSACCHARIDE ACCOUNT FOR ITS HIGH ANTICOAGULANT ACTION.
P. A.S. Mourao, M. S. Pereira, M. S.G. Pavao, B. Mulloy, D. M. Tollefsen, M.-C. Mowinckel, and U. Abildgaard (1996)
J. Biol. Chem. 271, 23973-23984
   Abstract »    Full Text »    PDF »
Heparinization of Medical Grade Polyurethanes.
R. Eloy, J. Belleville, M. C. Rissoan, and J. Baguet (1987)
J Biomater Appl 2, 475-519
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)