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Science 26 October 1979:
Vol. 206. no. 4417, pp. 470 - 471
DOI: 10.1126/science.504988
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Articles

Science, Vol 206, Issue 4417, 470-471
Copyright © 1979 by American Association for the Advancement of Science

articles

Phenylethylamine in paranoid chronic schizophrenia

SG Potkin, F Karoum, LW Chuang, HE Cannon-Spoor, I Phillips, and RJ Wyatt

Phenylethylamine (PEA) is an endogenous amine that is structurally and pharmacologically related to amphetamine. Urinary PEA excretion is significantly higher in paranoid chronic schizophrenics than in nonparanoid chronic schizophrenics and normal controls. Diet, hospitalization, and medication do not account for differences in PEA concentrations. These findings offer some indication that PEA may be an endogenous amphetamine.


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