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Science 26 October 1979:
Vol. 206. no. 4417, pp. 465 - 467
DOI: 10.1126/science.504986
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Articles

Science, Vol 206, Issue 4417, 465-467
Copyright © 1979 by American Association for the Advancement of Science

articles

Classification of opioids on the basis of change in seizure threshold in rats

A Cowan, EB Geller, and MW Adler

Twenty opioids have been subdivided into four classes by using flurothyl-induced seizures in rats to measure dose-response relationships, stereospecificity, naloxone sensitivity, and tolerance-cross-tolerance. The data support current theories of multiple opiate receptor types. Since the receptors involved mediate effects that are antagonized, enhanced, or unaffected by naloxone, the model is uniquely suitable for detecting novel narcotic antagonists that can then be used to differentiate opiate receptors in other systems.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Analytic Reviews : Neuropsychiatric Toxicity of Meperidine.
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J Intensive Care Med 3, 246-252
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Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure.
F. Tortella and J. Long (1985)
Science 228, 1106-1108
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