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Science 26 October 1979:
Vol. 206. no. 4417, pp. 456 - 462
DOI: 10.1126/science.228391
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Articles
Science, Vol 206, Issue 4417, 456-462
Copyright © 1979 by American Association for the Advancement of Science
BK virus DNA: complete nucleotide sequence of a human tumor virus
RC Yang
and
R Wu
The complete DNA sequence of the human papovavirus BK is presented. From the 4963 base-pair sequence of BK virus (MM strain), the amino acid sequence of at least five proteins can be deduced: a T antigen and a t antigen, which share amino terminal peptides; proteins VP2 and VP3, which share 232 amino acids; and protein VP1, whose coding sequence overlaps those for VP2 and VP3 by 113 nucleotides but is read in a different frame. The gene loci and the arrangement of genes are strikingly similar in BK virus and simian virus 40 (SV40). The sequence of the deduced proteins in BK virus shares 73 percent amino acid homology with those in SV40, whereas the DNA sequence of the two viruses shares 70 percent homology, suggesting close evolutionary relationship. However, the repeated DNA sequences in the noncoding regions of these viruses are different.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Conserved archetypal configuration of the transcriptional control region during the course of BK polyomavirus evolution.
- Y. Yogo, S. Zhong, Y. Xu, M. Zhu, Y. Chao, C. Sugimoto, H. Ikegaya, A. Shibuya, and T. Kitamura (2008)
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89, 1849-1856
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- Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.
- R. Gosert, C. H. Rinaldo, G. A. Funk, A. Egli, E. Ramos, C. B. Drachenberg, and H. H. Hirsch (2008)
J. Exp. Med.
205, 841-852
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- Identification of a genomic subgroup of BK polyomavirus spread in European populations..
- H. Ikegaya, P. J. Saukko, R. Tertti, K. P. Metsarinne, M. J. Carr, B. Crowley, K. Sakurada, H.-Y. Zheng, T. Kitamura, and Y. Yogo (2006)
J. Gen. Virol.
87, 3201-3208
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- Phylogenetic Analysis of Polyomavirus BK Sequences..
- P. M. Sharma, G. Gupta, A. Vats, R. Shapiro, and P. Randhawa (2006)
J. Virol.
80, 8869-8879
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- Cross-Reactivity of T Lymphocytes Recognizing a Human Cytotoxic T-Lymphocyte Epitope within BK and JC Virus VP1 Polypeptides.
- L. Krymskaya, M. C. Sharma, J. Martinez, W. Haq, E. C. Huang, A. P. Limaye, D. J. Diamond, and S. F. Lacey (2005)
J. Virol.
79, 11170-11178
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- Subtypes of BK virus prevalent in Japan and variation in their transcriptional control region.
- T. Takasaka, N. Goya, T. Tokumoto, K. Tanabe, H. Toma, Y. Ogawa, S. Hokama, A. Momose, T. Funyu, T. Fujioka, et al. (2004)
J. Gen. Virol.
85, 2821-2827
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- Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity.
- Y. Chen, P. M. Sharp, M. Fowkes, O. Kocher, J. T. Joseph, and I. J. Koralnik (2004)
J. Gen. Virol.
85, 2651-2663
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- The Agnogene of the Human Polyomavirus BK Is Expressed.
- C. H. Rinaldo, T. Traavik, and A. Hey (1998)
J. Virol.
72, 6233-6236
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- BK viral enhancer element and a human cellular homolog.
- N Rosenthal, M Kress, P Gruss, and G Khoury (1983)
Science
222, 749-755
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- Silent nucleotide substitutions and the molecular evolutionary clock.
- T. Jukes (1980)
Science
210, 973-978
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