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Science 19 October 1979:
Vol. 206. no. 4416, pp. 347 - 349
DOI: 10.1126/science.314668
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Articles

Science, Vol 206, Issue 4416, 347-349
Copyright © 1979 by American Association for the Advancement of Science

articles

Monoclonal antibodies defining distinctive human T cell surface antigens

P Kung, G Goldstein, EL Reinherz, and SF Schlossman

Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.


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