Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 19 October 1979:
Vol. 206. no. 4416, pp. 347 - 349
DOI: 10.1126/science.314668

Articles

Science, Vol 206, Issue 4416, 347-349
Copyright © 1979 by American Association for the Advancement of Science


articles

Monoclonal antibodies defining distinctive human T cell surface antigens

P Kung, G Goldstein, EL Reinherz, and SF Schlossman

Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
V. Orru, S. J. Tsai, B. Rueda, E. Fiorillo, S. M. Stanford, J. Dasgupta, J. Hartiala, L. Zhao, N. Ortego-Centeno, S. D'Alfonso, et al. (2009)
Hum. Mol. Genet. 18, 569-579
   Abstract »    Full Text »    PDF »
TCR Complex-Activated CD8 Adhesion Function by Human T Cells.
J. C. Varghese and K. P. Kane (2008)
J. Immunol. 181, 6002-6009
   Abstract »    Full Text »    PDF »
Telomeres, stem cells, and hematology.
P. M. Lansdorp (2008)
Blood 111, 1759-1766
   Abstract »    Full Text »    PDF »
Molecular Characterization of the Anti-Idiotypic Immune Response of a Relapse-Free Neuroblastoma Patient following Antibody Therapy: A Possible Vaccine against Tumors of Neuroectodermal Origin?.
M. M. Uttenreuther-Fischer, J. A. Kruger, and P. Fischer (2006)
J. Immunol. 176, 7775-7786
   Abstract »    Full Text »    PDF »
CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.
R. Pacheco, J. M. Martinez-Navio, M. Lejeune, N. Climent, H. Oliva, J. M. Gatell, T. Gallart, J. Mallol, C. Lluis, and R. Franco (2005)
PNAS 102, 9583-9588
   Abstract »    Full Text »    PDF »
Group I Metabotropic Glutamate Receptors Mediate a Dual Role of Glutamate in T Cell Activation.
R. Pacheco, F. Ciruela, V. Casado, J. Mallol, T. Gallart, C. Lluis, and R. Franco (2004)
J. Biol. Chem. 279, 33352-33358
   Abstract »    Full Text »    PDF »
Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody.
F. Le Gall, U. Reusch, M. Little, and S. M. Kipriyanov (2004)
Protein Eng. Des. Sel. 17, 357-366
   Abstract »    Full Text »    PDF »
Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation.
P. Jullien, R. Q. Cron, K. Dabbagh, A. Cleary, L. Chen, P. Tran, P. Stepick-Biek, and D. B. Lewis (2003)
Int. Immunol. 15, 1461-1472
   Abstract »    Full Text »    PDF »
CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes.
R. V. Parry, C. A. Rumbley, L. H. Vandenberghe, C. H. June, and J. L. Riley (2003)
J. Immunol. 171, 166-174
   Abstract »    Full Text »    PDF »
Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival.
E. K. Deenick, A. V. Gett, and P. D. Hodgkin (2003)
J. Immunol. 170, 4963-4972
   Abstract »    Full Text »    PDF »
SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production.
T. Ishii, K. Ohnuma, A. Murakami, N. Takasawa, T. Yamochi, S. Iwata, M. Uchiyama, N. H. Dang, H. Tanaka, and C. Morimoto (2003)
J. Immunol. 170, 3653-3661
   Abstract »    Full Text »    PDF »
Heart Transplantation.
B. T. Bethea, D. D. Yuh, J. V. Conte, and W. A. Baumgartner (2003)
Card. Surg. Adult 2, 1427-1460
   Full Text »
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation.
B. Kovacs, M. V. Maus, J. L. Riley, G. S. Derimanov, G. A. Koretzky, C. H. June, and T. H. Finkel (2002)
PNAS 99, 15006-15011
   Abstract »    Full Text »    PDF »
Double Signal Stimulation Was Required for Full Recovery of the Autologous Tumor-Killing Effect of Effusion-Associated Lymphocytes.
Y.-M. Chen, C.-M. Tsai, J. Whang-Peng, and R.-P. Perng (2002)
Chest 122, 1421-1427
   Abstract »    Full Text »    PDF »
Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4.
L. Li, D. Liu, L. Hutt-Fletcher, A. Morgan, M. G. Masucci, and V. Levitsky (2002)
Blood 99, 3725-3734
   Abstract »    Full Text »    PDF »
Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation.
E. Y. Woo, H. Yeh, C. S. Chu, K. Schlienger, R. G. Carroll, J. L. Riley, L. R. Kaiser, and C. H. June (2002)
J. Immunol. 168, 4272-4276
   Abstract »    Full Text »    PDF »
Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide.
M. Maurice, E. Verhoeyen, P. Salmon, D. Trono, S. J. Russell, and F.-L. Cosset (2002)
Blood 99, 2342-2350
   Abstract »    Full Text »    PDF »
ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement.
J. L. Riley, P. J. Blair, J. T. Musser, R. Abe, K. Tezuka, T. Tsuji, and C. H. June (2001)
J. Immunol. 166, 4943-4948
   Abstract »    Full Text »    PDF »
Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5.
K. M. Dennehy, W. F. Ferris, H. Veenstra, L. A. Zuckerman, N. Killeen, and A. D. Beyers (2001)
Int. Immunol. 13, 149-156
   Abstract »    Full Text »    PDF »
Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation.
D. Filipp, K. Alizadeh-Khiavi, C. Richardson, A. Palma, N. Paredes, O. Takeuchi, S. Akira, and M. Julius (2001)
PNAS 98, 603-608
   Abstract »    Full Text »    PDF »
Structural and Functional Dissection of Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules.
S. Lee, J. Yoon, B. Park, Y. Jun, M. Jin, H. C. Sung, I.-H. Kim, S. Kang, E.-J. Choi, B. Y. Ahn, et al. (2000)
J. Virol. 74, 11262-11269
   Abstract »    Full Text »
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation.
X. Shan, M. J. Czar, S. C. Bunnell, P. Liu, Y. Liu, P. L. Schwartzberg, and R. L. Wange (2000)
Mol. Cell. Biol. 20, 6945-6957
   Abstract »    Full Text »
Treatment of Human B Cell Lymphoma Xenografts with a CD3 CD19 Diabody and T Cells.
B. Cochlovius, S. M. Kipriyanov, M. J. J. G. Stassar, O. Christ, J. Schuhmacher, G. Strau{beta}, G. Moldenhauer, and M. Little (2000)
J. Immunol. 165, 888-895
   Abstract »    Full Text »    PDF »
Human Aggression and Enumerative Measures of Immunity.
D. A. Granger, A. Booth, and D. R. Johnson (2000)
Psychosom Med 62, 583-590
   Abstract »    Full Text »    PDF »
Adoption of Single-Platform Technologies for Enumeration of Absolute T-Lymphocyte Subsets in Peripheral Blood.
M. R. G. O'Gorman and J. K. A. Nicholson (2000)
Clin. Vaccine Immunol. 7, 333-335
   Full Text »    PDF »
CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells.
G. Sconocchia, J. A. Titus, A. Mazzoni, A. Visintin, F. Pericle, S. W. Hicks, F. Malavasi, and D. M. Segal (1999)
Blood 94, 3864-3871
   Abstract »    Full Text »    PDF »
Induction immunosuppression for lung transplantation with OKT3.
J. C. Wain, C. D. Wright, D. P. Ryan, S. L. Zorb, D. J. Mathisen, and L. C. Ginns (1999)
Ann. Thorac. Surg. 67, 187-193
   Abstract »    Full Text »    PDF »
Naive and Memory CD4 T Cells Differ in Their Susceptibilities to Human Immunodeficiency Virus Type 1 Infection following CD28 Costimulation: Implications for Transmission and Pathogenesis.
J. L. Riley, B. L. Levine, N. Craighead, T. Francomano, D. Kim, R. G. Carroll, and C. H. June (1998)
J. Virol. 72, 8273-8280
   Abstract »    Full Text »    PDF »
Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression.
P. R. Mittelstadt and J. D. Ashwell (1998)
Mol. Cell. Biol. 18, 3744-3751
   Abstract »    Full Text »
Oxidized Low Density Lipoproteins in Patients With Transplant-Associated Coronary Artery Disease.
P. Holvoet, J.-M. Stassen, J. Van Cleemput, D. Collen, and J. Vanhaecke (1998)
Arterioscler Thromb Vasc Biol 18, 100-107
   Abstract »    Full Text »    PDF »
Regulation of ZAP-70 Intracellular Localization: Visualization with the Green Fluorescent Protein.
J. Sloan-Lancaster, W. Zhang, J. Presley, B. L. Williams, R. T. Abraham, J. Lippincott-Schwartz, and L. E. Samelson (1997)
J. Exp. Med. 186, 1713-1724
   Abstract »    Full Text »    PDF »
Functional Interactions Between the Thrombin Receptor and the T-Cell Antigen Receptor in Human T-Cell Lines.
D. E. Joyce, Y. Chen, R. A. Erger, G. A. Koretzky, and S. R. Lentz (1997)
Blood 90, 1893-1901
   Abstract »    Full Text »    PDF »
In Vitro Translation and Assembly of a Complete T Cell Receptor-CD3 Complex.
J. B. Huppa and H. L. Ploegh (1997)
J. Exp. Med. 186, 393-403
   Abstract »    Full Text »    PDF »
Infection with Human Immunodeficiency Virus Type 1 (HIV-1) among Recipients of Antibody-Positive Blood Donations.
E. Donegan, M. Stuart, J. C. Niland, H. S. Sacks, S. P. Azen, S. L. Dietrich, C. Faucett, M. A. Fletcher, S. H. Kleinman, E. A. Operskalski, et al. (1990)
Ann Intern Med 113, 733-739
   Abstract »    PDF »
Monoclonal Antibody--Defined Lymphocyte Subsets in Normal Nigerians.
M.O. Adedeji (1989)
Angiology 40, 977-981
   Abstract »    PDF »
Subacute Cutaneous Lupus Erythematosus: Genetic Markers and Clinical and Immunological Findings in Patients.
E. Johansson-Stephansson, S. Koskimies, J. Partanen, and A.-L. Kariniemi (1989)
Arch Dermatol 125, 791-796
   Abstract »    PDF »
Structure and Regulation of the Leukocyte Adhesion Receptor LFA-1 and Its Counterreceptors, ICAM-1 and ICAM-2.
M.L. Dustin, J. Garcia-Aguilar, M.L. Hibbs, R.S. Larson, S.A. Stacker, D.E. Staunton, A.J. Wardlaw, and T.A. Springer (1989)
Cold Spring Harb Symp Quant Biol 54, 753-765
   Abstract »    PDF »
A Prospective Study on the Use of Monoclonal Anti--T3-Cell Antibody (OKT3) to Treat Steroid-Resistant Liver Transplant Rejection.
J. O. Colonna II, L. I. Goldstein, J. J. Brems, J. H. Vargas, J. E. Brill, W. J. Berquist, J. R. Hiatt, and R. W. Busuttil (1987)
Arch Surg 122, 1120-1123
   Abstract »    PDF »
Lymphocyte Subsets in Normal Airway Mucosa of the Human Nose.
B. Winther, D. J. Innes Jr, S. E. Mills, N. Mygind, D. Zito, and F. G. Hayden (1987)
Arch Otolaryngol Head Neck Surg 113, 59-62
   Abstract »    PDF »
Determination of junction avidity of cytolytic T cell and target cell.
K. Sung, L. Sung, M Crimmins, S. Burakoff, and S Chien (1986)
Science 234, 1405-1408
   Abstract »    PDF »
Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line.
D. Tse, M Al-Haideri, B Pernis, C. Cantor, and C. Wang (1986)
Science 234, 748-751
   Abstract »    PDF »
Lack of Modulation of Postoperative Immunosuppression by Isotonic Amino Acid Infusion.
P. Neuvonen, M. Salo, J. Perttila, and T. Havia (1986)
JPEN J Parenter Enteral Nutr 10, 160-165
   Abstract »    PDF »
Prevention of Posttraumatic Alterations in Lymphocyte Subpopulations in Mice by Immunomodulating Drugs.
R. Zapata-Sirvent, J. F. Hansbrough, and E. J. Bartle (1986)
Arch Surg 121, 116-122
   Abstract »    PDF »
Fatal Epstein-Barr-Virus-Associated Proliferation of Donor B Cells After Treatment of Acute Graft-Versus-Host Disease with a Murine Anti-T-Cell Antibody.
P. J. MARTIN, H. M. SHULMAN, W. H. SCHUBACH, J. A. HANSEN, A. FEFER, G. MILLER, and E. D. THOMAS (1984)
Ann Intern Med 101, 310-315
   Abstract »    PDF »
T Cells and T-Cell Subsets in Mycosis Fungoides and Parapsoriasis: A Study of 18 Cases With Anti-Human T-Cell Monoclonal Antibodies and Histochemical Techniques.
S. A. Buechner, R. K. Winkelmann, and P. M. Banks (1984)
Arch Dermatol 120, 897-905
   Abstract »    PDF »
T Cells in Cutaneous Lesions of Sezary Syndrome and T-Cell Leukemia: Characterization by Monoclonal Antibodies.
S. A. Buechner, R. K. Winkelmann, and P. M. Banks (1983)
Arch Dermatol 119, 895-900
   Abstract »    PDF »
T-Cell Subsets in Cutaneous Sarcoidosis.
S. A. Buechner, R. K. Winkelmann, and P. M. Banks (1983)
Arch Dermatol 119, 728-732
   Abstract »    PDF »
An Immunologic Evaluation of Hemophiliac Patients and Their Wives: Relationships to the Acquired Immunodeficiency Syndrome.
R. D. deSHAZO, W. A. ANDES, J. NORDBERG, J. NEWTON, C. DAUL, and B. BOZELKA (1983)
Ann Intern Med 99, 159-164
   Abstract »    PDF »
Transition from Systemic Lupus Erythematosus to Common Variable Hypogammaglobulinemia.
G. L. SUSSMAN, V. J. RIVERA, and P. F. KOHLER (1983)
Ann Intern Med 99, 32-35
   Abstract »    PDF »
T6-Antigen--Bearing Cells in Eosinophilic Granuloma of Bone.
J. L. Fox and B. Berman (1983)
JAMA 249, 3071-3072
   Abstract »    PDF »
Monoclonal Antibodies: Powerful New Tools for the Clinician.
C. L. Berger and R. Edelson (1982)
Arch Dermatol 118, 627-629
   Abstract »    PDF »
Disseminated Kaposi's Sarcoma in Homosexual Men.
A. E. FRIEDMAN-KIEN, L. J. LAUBENSTEIN, P. RUBINSTEIN, E. BUIMOVICI-KLEIN, M. MARMOR, R. STAHL, I. SPIGLAND, K. S. KIM, and S. ZOLLA-PAZNER (1982)
Ann Intern Med 96, 693-700
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)