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Science 12 October 1979:
Vol. 206. no. 4415, pp. 222 - 225
DOI: 10.1126/science.482937
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Articles

Science, Vol 206, Issue 4415, 222-225
Copyright © 1979 by American Association for the Advancement of Science

articles

Calcification of differentiating skeletal mesenchyme in vitro

I Binderman, RM Greene, and JP Pennypacker

Embryonic limb-bud mesenchyme was induced to calcify in culture by the addition of 3 mM inorganic phosphate to the medium. Phosphate enhanced calcification of the matrix produced by mesenchymal or fibroblast-like cells, whereas no calcification was evident in areas where cartilage had developed. However, calcification was induced throughout the cell layer by altering the cartilage matrix properties with certain enzymes or by changing the phenotypic expression of the cells with vitamin A.


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Dishing up bone formation.
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J. Cell Biol. 171, 409
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Role of Organic Phosphate in Mineralization of Bone in vitro.
H.C. Tenenbaum (1981)
Journal of Dental Research 60, 1586-1589
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