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Science 5 October 1979:
Vol. 206. no. 4414, pp. 89 - 91
DOI: 10.1126/science.39340
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Articles

Science, Vol 206, Issue 4414, 89-91
Copyright © 1979 by American Association for the Advancement of Science

articles

Effect of beta-endorphin on calcium uptake in the brain

F Guerrero-Munoz, M de Lourdes Guerrero, EL Way, and CH Li

The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.


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