Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 October 1979:
Vol. 206. no. 4414, pp. 85 - 87
DOI: 10.1126/science.482930
Prev | Table of Contents | Next

Articles

Science, Vol 206, Issue 4414, 85-87
Copyright © 1979 by American Association for the Advancement of Science

articles

Serotonin neurons project to small blood vessels in the brain

JF Reinhard Jr, JE Liebmann, AJ Schlosberg, and MA Moskowitz

Electrolytic lesions of the nucleus raphe dorsalis and medianus reduce the concentration of serotonin (5-hydroxytryptamine) within rat brain intraparenchymal blood vessels. The concentration of serotonin within these vessels increases or decreases after the administration of drugs that modify the biosynthesis and degradation of serotonin or destroy nerve terminals by an uptake-dependent mechanism. These studies provide evidence for the existence of a serotonin-containing pathway seemingly analogous to the neuronal projection that terminates on small parenchymal blood vessels from noradrenergic neurons of the locus coeruleus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cat Cerebral Arteries Are Functionally Innervated by Serotoninergic Fibers From Central and Peripheral Origins.
M. J. Moreno, A. L. L. de Pablo, M. V. Conde, and E. J. Marco (1995)
Stroke 26, 271-276
   Abstract »    Full Text »
Bilateral Spreading Cerebral Hypoperfusion during Spontaneous Migraine Headache.
R. P. Woods, M. Iacoboni, and J. C. Mazziotta (1994)
N. Engl. J. Med. 331, 1689-1692
   Full Text »
Neurotransmitter receptor binding in bovine cerebral microvessels.
S. Peroutka, M. Moskowitz, J. Reinhard Jr, and S. Snyder (1980)
Science 208, 610-612
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)