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ArticlesCopyright © 1979 by American Association for the Advancement of Science
Inhibition of histaminase release from human granulocytes by products of histaminase activity
Imidazoleacetic acid, a product of the action of histaminase (E.C. 1.4.3.6) on histamine, inhibits specific release of histaminase from human peripheral blood granulocytes with an inhibition constant between 5 X 10(-9)M and 1 X 10(-8)M. Hence, modulation of enzyme release is indirectly mediated by the activity of the enzyme.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)