Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
American Society for Biochemistry and Molecular Biology

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 September 1979:
Vol. 205. no. 4413, pp. 1412 - 1414
DOI: 10.1126/science.472759
Prev | Table of Contents | Next

Articles

Science, Vol 205, Issue 4413, 1412-1414
Copyright © 1979 by American Association for the Advancement of Science

articles

Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils

JE Niedel, I Kahane, and P Cuatrecasas

Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37 degrees C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formal peptide chemotactic receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pharmacological Potentiation of Natriuretic Peptide Limits Polymorphonuclear Neutrophil-Vascular Cell Interactions.
E. M. Mtairag, X. Houard, S. Rais, C. Pasquier, M. Oudghiri, M.-P. Jacob, O. Meilhac, and J.-B. Michel (2002)
Arterioscler. Thromb. Vasc. Biol. 22, 1824-1831
   Abstract »    Full Text »    PDF »
Assessment of neutrophil N-formyl peptide receptors by using antibodies and fluorescent peptides.
V.-M. Loitto, B. Rasmusson, and K.-E. Magnusson (2001)
J. Leukoc. Biol. 69, 762-771
   Abstract »    Full Text »
Chemotactic properties, cellular binding and uptake of peptides and peptide derivatives: studies with Tetrahymena thermophila.
V. Leick (1992)
J. Cell Sci. 103, 565-570
   Abstract »    PDF »
Molecular and cellular mechanisms of leukocyte chemotaxis.
R Snyderman and E. Goetzl (1981)
Science 213, 830-837
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)