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Science 28 September 1979: Vol. 205. no. 4413, pp. 1412 - 1414 DOI: 10.1126/science.472759
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Articles
Science, Vol 205, Issue 4413, 1412-1414
Copyright © 1979 by American Association for the Advancement of Science
Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils
JE Niedel,
I Kahane,
and
P Cuatrecasas
Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37 degrees C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formal peptide chemotactic receptor.
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