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Science 28 September 1979:
Vol. 205. no. 4413, pp. 1412 - 1414
DOI: 10.1126/science.472759
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Articles

Science, Vol 205, Issue 4413, 1412-1414
Copyright © 1979 by American Association for the Advancement of Science

articles

Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils

JE Niedel, I Kahane, and P Cuatrecasas

Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37 degrees C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formal peptide chemotactic receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family.
R. D. Ye, F. Boulay, J. M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C. N. Serhan, and P. M. Murphy (2009)
Pharmacol. Rev. 61, 119-161
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Pharmacological Potentiation of Natriuretic Peptide Limits Polymorphonuclear Neutrophil-Vascular Cell Interactions.
E. M. Mtairag, X. Houard, S. Rais, C. Pasquier, M. Oudghiri, M.-P. Jacob, O. Meilhac, and J.-B. Michel (2002)
Arterioscler Thromb Vasc Biol 22, 1824-1831
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Assessment of neutrophil N-formyl peptide receptors by using antibodies and fluorescent peptides.
V.-M. Loitto, B. Rasmusson, and K.-E. Magnusson (2001)
J. Leukoc. Biol. 69, 762-771
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Chemotactic properties, cellular binding and uptake of peptides and peptide derivatives: studies with Tetrahymena thermophila.
V. Leick (1992)
J. Cell Sci. 103, 565-570
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Neutrophil Function And Oral Disease.
T. E. Van Dyke and G. A. Hoop (1990)
Critical Reviews in Oral Biology & Medicine 1, 117-133
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1985 Kreshover lecture. Molecular Factors Influencing Neutrophil Defects in Periodontal Disease.
R.J. Genco, T.E. Van Dyke, M.J. Levine, R.D. Nelson, and M.E. Wilson (1986)
Journal of Dental Research 65, 1379-1391
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Neutrophil Receptor Modulation in the Pathogenesis of Periodontal Diseases.
T.E. Van Dyke (1984)
Journal of Dental Research 63, 452-454
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Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features.
K. M. Skubitz, P. R. Craddock, D. J. Weisdorf, J. E. Niedel, T. W. LeBien, J. H. Kersey, R. D. Brunning, J. L. Parkin, P. J. Flynn, and D. E. Hammerschmidt (1983)
JAMA 250, 2957-2960
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Molecular and cellular mechanisms of leukocyte chemotaxis.
R Snyderman and E. Goetzl (1981)
Science 213, 830-837
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Induction of Ocular Inflammation by Synthetic Mediators.
A. Ben-Zvi, M. M. Rodrigues, I. Gery, and E. Schiffmann (1981)
Arch Ophthalmol 99, 1436-1444
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