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Science 28 September 1979:
Vol. 205. no. 4413, pp. 1409 - 1412
DOI: 10.1126/science.224464
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Articles

Science, Vol 205, Issue 4413, 1409-1412
Copyright © 1979 by American Association for the Advancement of Science

articles

Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons

JD Vincent and JL Barker

Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)